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Literature summary extracted from

  • Tsirkone, V.G.; Dossi, K.; Drakou, C.; Zographos, S.E.; Kontou, M.; Leonidas, D.D.
    Inhibitor design for ribonuclease A: the binding of two 5-phosphate uridine analogues (2009), Acta Crystallogr. Sect. F, 65, 671-677.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.6.1.18 vapor-diffusion, hanging-drop, PEG 4000, sodium citrate, pH 5.5, temperature 289 K, ribonuclease A-uridine 5’ phosphate complex, resolution 1.39 A, space group C121, ribonuclease A-uridine 5’ diphosphate complex, resolution 1.40 A, space group C121 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.18 uridine 5'-diphosphate competitive inhibitor Bos taurus
4.6.1.18 uridine 5'-phosphate competitive inhibitor Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Bos taurus P61823
-
-

Synonyms

EC Number Synonyms Comment Organism
4.6.1.18 pancreatic ribonuclease A
-
 Bos taurus
4.6.1.18 RNase A
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.6.1.18 0.65
-
 uridine 5'-diphosphate binds to the active site of the enzyme by anchoring two molecules connected to each other by hydrogen bonds and van der Waals interactions Bos taurus
4.6.1.18 4
-
 uridine 5'-phosphate binds to the active site of the enzyme by anchoring two molecules connected to each other by hydrogen bonds and van der Waals interactions Bos taurus